en Nursing Original Article <div style="text-align: justify;"><span style="font-size:12px;"><span style="font-family:Times New Roman;"><b>Background:</b> Chronic obstructive pulmonary disease (COPD) is a progressive, irreversible respiratory condition that imposes a significant physical and psychological burden, often leading to a poor quality of life. Although palliative care can help address these challenges, in Iran it is typically limited to cancer patients and is not commonly provided to those with COPD. Globally, the early integration of palliative care for chronic illnesses is expanding. The present study aims to investigate the feasibility and acceptability of an early tele-palliative care intervention for patients with COPD in Iran and to explore its potential effects on quality of life, anxiety, depression, and emergency department readmissions.<br> <b>Methods:</b> This randomized controlled feasibility trial protocol involves a 3-month early tele-palliative care program delivered by two nurse coaches, targeting patients with COPD. Participantswere randomly assigned to either the intervention group (n = 26) or the control group (n = 26) using permuted block randomization. Both groups received traditional COPD care; however, the intervention group also received six weekly telephone sessions and six weeks of follow-up support via phone call and WhatsApp Messenger. The primary objective was to assess the feasibility and acceptability of early tele-palliative care, measured through recruitment and attrition rates, questionnaire completion rates, patient satisfaction, attitudes toward the intervention, and adherence to the intervention. The secondary outcome included changes in quality of life, anxiety, depression, and hospital readmissions. These were measured using validated instruments at two time points: Baseline (pre-intervention) and three months post-intervention. Statistical analyses were performed using SPSS version 22, including the independent samples t-test, paired samples t-test, chi-square test, and Fisher&rsquo;s exact test. Analysis of covariance (ANCOVA) was used to compare the mean outcomes between the two groups while statistically controlling for the effect of baseline values. Statistical significance was set at p < 0.05.<br> <b>Conclusion</b>: This study protocol aimed to determine the feasibility and acceptability of an early tele-palliative care intervention for patients with COPD in Iran. The findings provided essential data to inform the design of a future large-scale clinical trial and support the potential integration of early telehealth palliative care into standard COPD management in the country.</span></span><br> &nbsp;</div> Pulmonary disease, Chronic obstructive, Telehealth, Palliative care, Quality of life, Feasibility studies 14 21 http://nmj.goums.ac.ir/browse.php?a_code=A-10-2171-1&slc_lang=en&sid=1 Zahra Arabi Zahraarabi7798@gmail.com 100319475328460016948 0009-0003-4726-8602 No Department of Medical-Surgical Nursing, School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, Iran Arvin Mirshahi Mirshahiarvin13750@gmail.com 100319475328460016949 100319475328460016949 No Students’ Scientific Research Center, Department of Medical-Surgical Nursing, School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, Iran; Center for Palliative and Supportive Care, University of Alabama at Birmingham, Birmingham, Alabama, United States of America Hosein Kazemi Zadeh hokkazemizadeh@gmail.com 100319475328460016950 100319475328460016950 No Department of Pulmonology, School of Medicine, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran Shima Haghani shima_haghani@yahoo.com 100319475328460016951 100319475328460016951 No Biostatistics Nursing Care Research Center, Iran University of Medical Sciences, Tehran, Iran Anand Iyer aiyer@uabmc.edu 100319475328460016952 100319475328460016952 No Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America Rachel Wells raduncan@uab.edu 100319475328460016953 100319475328460016953 No School of Nursing, University of Alabama at Birmingham, Birmingham, Alabama, United States of America Marie Bakitas mbakitas@uab.edu 100319475328460016954 100319475328460016954 No Center for Palliative and Supportive Care, University of Alabama at Birmingham, Birmingham, Alabama, United States of America; Department of Medicine, School of Nursing, Division of Gerontology, Geriatrics, and Palliative Care, University of Alabama at Birmingham, Birmingham, Alabama, United States of America Mehraban Shahmari mehrabanshahmari@yahoo.com 100319475328460016955 100319475328460016955 No Department of Medical‐Surgical, School of Nursing and Midwifery, Ardabil University of Medical Sciences, Ardabil, Iran Arpi Manookian Manookianarpi@gmail.com 100319475328460016956 100319475328460016956 Yes Department of Medical-Surgical Nursing, School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, Iran