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Delaram M, Sadeghian Z, Parvin N, Kazemiyan A, Shams S. Comparison of Analgesic Effect of Agnogol with Mefenamic Acid in the Treatment of Primary Dysmenorrhea. J Res Dev Nurs Midw 2015; 12 (1) :1-7
URL: http://nmj.goums.ac.ir/article-1-699-en.html

Material and Methods: This clinical trial was conducted on 44 women with primary dysmenorrhea referred to Hajar hospital in Shahrekord. The participants were randomly allocated to two groups of Agnogol (n=23) to use one 3.2 mg Agnogol pill for three times a day and Mefenamic Acid (n=21) to use 250 mg Mefenamic acid every 8 hours a day for three days. The pain severity was detected by Visual Analogue Scale. We used Independent and Paired t test for comparing the means of quantitative variables and Chi Square for qualitative variables ( P<0.05 ). 

Results: Considering age, menstrual duration, menstrual interval, and pain severity score, there was no significant difference in two groups at the beginning of the study (P>0.05). After intervention, a significant reduction was found in the mean of pain score over time in both Agnogol (P<0.001) and Mefenamic acid (P<0.001) groups, but the difference between two groups was not significant (P>0.05). 

Conclusion: Given the same effect of Agnogol in mitigating dysmenorrhea, we recommend it as an appropriate alternative for Mefenamic acid.